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FDA Issues Emergency Use Authorization for Third COVID-19 Vaccine
Action Advances Fight Against COVID-19, Follows Comprehensive Evaluation of Available Safety, Effectiveness and Manufacturing Quality Information by FDA Career Scientists, Input from External Experts Today, the U.S. Food and Drug Administration issued an emergency use...
Semaglutide for Weight Loss? A Good First STEP, With Caveats
The phase 3a STEP 1 trial that investigated the use of semaglutide (Novo Nordisk), a glucagon-like peptide-1 (GLP-1) agonist, for weight loss is aptly named, some say. "In sum, we have a long way to go to control the obesity epidemic...but on the face of it, the STEP...
Lilly’s tirzepatide significantly reduced A1C and body weight in people with type 2 diabetes
More than half of participants taking the highest dose achieved normal A1C levels, a key secondary endpoint in first phase 3 trial of SURPASS program Participants in this monotherapy study had relatively recently diagnosed diabetes, with a mean duration of 4.7 years...
COVID-19 Vaccines in Late-Stage Development
Vaccines in Late-Stage Development The following vaccines are in, or have completed, phase 3 clinical trials in the United States. On December 18, 2020, the US Food and Drug Administration (FDA) granted Emergency Use Authorization (EUA) for the mRNA-1273 SARS-CoV-2...
Why Short-Term Cuts to Medicaid Coverage During Pregnancy and Childhood Could Result in Long-Term Harm
ABSTRACT Issue: States are facing large revenue shortfalls and budget deficits from the COVID-19 crisis. To close deficits, they will need to raise taxes, cut spending to critical public programs like Medicaid, or both. Goals: Examine the long-term benefits of...
Estimates of the Initial Priority Population for COVID-19 Vaccination by State
On December 1, 2020, the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention’s (CDC), issued an initial recommendation, adopted by the CDC director, that health care personnel and residents of long-term care facilities...
Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic
Key Points Question What are the fitted filtration efficiencies (FFEs) of consumer-grade masks, improvised face coverings, and modified procedure masks commonly used during the coronavirus disease 2019 (COVID-19) pandemic? Findings In this comparative study of face...
America’s Looming Primary-Care Crisis
Beverly Jordan is a partner at a family-medicine clinic in Enterprise, Alabama. Enterprise is situated in “wiregrass country”—a largely rural region, encompassing southeastern Alabama and parts of Georgia and Florida, named for the ubiquitous vegetation that takes...
Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020 American Diabetes Association’s Standards of Medical Care in Diabetes Clinical Guideline
Description: The American Diabetes Association (ADA) updates the Standards of Medical Care in Diabetes annually to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of...
Lower Back Pain: NSAID + Muscle Relaxant No Better Than NSAID + Placebo
Patients with lower back pain prescribed skeletal muscle relaxants in addition to NSAIDs report the same outcomes as placebo plus NSAIDs, new research shows. "Combining a skeletal muscle relaxant with an NSAID does not confer any additional benefit," Lorena Abril, MD,...
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